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Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
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Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
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Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
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Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.

Journal: Biomedicines

Article Title: Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator

doi: 10.3390/biomedicines14030687

Figure Lengend Snippet: Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.

Article Snippet: A dextran sulfate sodium (DSS)-induced colitis model was generated with 2.5% DSS (MP Biomedicals, molecular weight 35,000–50,000 Da).

Techniques: Western Blot, Expressing, Knockdown, Activity Assay, Staining